(2012), Beisel CL, Storz G Finally, Professor Chase Beisel has accepted a position as leader of the RNA Synthetic Biology research group at the Helmholtz Institute for RNA-based infection research (HIRI) in Würzburg, Germany, and eventually will be leaving his position as a tenured associate professor. (2017), Journal of Molecular Biology, 429 (2): 177-191, Waller MC, Bober JR, Nair NU, Beisel CL (2010), FEMS Microbiology Reviews, 34 (5): 866-82, Bayer TS, Hoff KG, Beisel CL, Lee JJ, Smolke CD (2015), Angewandte Chemie International Edition, 54 (41): 12029-33, Afroz T, Biliouris K, Boykin KE, Kaznessis Y, Beisel CL We are also using these insights to advance how we study infectious disease and how we combat multidrug-resistant infections. 2020 Jan 31. pii: AEM.02312-19. Collias D, Leenay RT, Slotkowski RA, Zuo Z, Collins SP, McGirr BA, Liu J, Beisel CL IMAGE: This is Chase Beisel view more Credit: Mario Schmitt. (2019), Collias D, Marshall R, Collins SP, Beisel CL, Noireaux V and his PhD in chemical engineering from the California Institute of Technology, and he held a postdoctoral fellowship in bacterial genetics at the National Institutes of Health (NIH). (2017), Leenay RT, Beisel CL However, the past decade has revealed a myriad of other functions that continues to reshape our understanding of this versatile biomolecule. These same properties can be harnessed to create a new generation of engineering tools to further interrogate the properties of biology and control how cells behave. Dr. Beisel received his BS in chemical engineering from Iowa State Univ. These systems consist of two general parts: Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) arrays and CRISPR-associated (Cas) proteins. Movie presentation followed by a discussion with HIRI scientists Jörg Vogel and Chase Beisel. (2009), Beisel CL, Bayer TS, Hoff KG, Smolke CD edited by Maeola Beitzel The HIRI is a joint institution of the Helmholtz Centre for Infection Research (HZI) in Braunschweig and the Julius Maximilian University of Würzburg. The Beisel lab is looking for motivated and collaborative scientists and engineers to join our research group. Beisel Lab, Helmholtz-Institut für RNA-basierte Infektionsforschung (HIRI) May 2019 – Aug 2019 4 months. ”Until now, no fine-grained transcriptome annotation – a map of the entirety of RNA molecules – was available. Chase is selected to receive the 2018 D.I.C. (2019), Vento JM, Crook N, Beisel CL Chase L. Beisel, PhD, is a group leader in the Helmholtz Institute for RNA-based Infection Research. CRISPR arrays represent the immunological memory of prior infections encoded within individua… EMBO J (2012) 31:1961-74 pubmed article See comment in Faculty of 1000; Beisel CL & Storz G. Discriminating tastes: physiological contributions of the Hfq-binding small RNA Spot 42 to catabolite repression. (2018), Beisel CL (2018), Bober JR, Beisel CL, Nair NU This was about 92% of all the recorded Beisel's in the USA. We explore the diversity of these systems found in nature and how their basic components, mechanisms, and functions can be harnessed for a new generation of CRISPR technologies. [Epub ahead of print] Competitive exclusion is a major bioprotective mechanism of lactobacilli against fungal spoilage in fermented milk products. (2015), Luo ML, Mullis AS, Leenay RT, Beisel CL We are exploring the full diversity of these immune systems in nature and how their functions have evolved to protect microbes against foreign invaders. (2020), Wimmer F, Beisel CL We are interested in understanding and engineering CRISPR-Cas systems. (2008), Beisel CL, Dowd MK, Reilly PJ These prokaryotic immune systems are responsible for fending off selfish genetic elements such as plasmids or bacteriophages, yet their basic components have been co-opted as revolutionary tools for genome editing in bacteria and yeast through plants, animals, and even humans. Cas12a nuclease recognizes GTTV and GCTV as non-canonical PAMs, Bacterial Adaptation to the Host's Diet Is a Key Evolutionary Force Shaping Drosophila-Lactobacillus Symbiosis, Rapid and Scalable Characterization of CRISPR Technologies Using an E. coli Cell-Free Transcription-Translation System, CRISPR RNA-Dependent Binding and Cleavage of Endogenous RNAs by the Campylobacter jejuni Cas9, Advances in CRISPR Technologies for Microbial Strain Engineering, Synthetic Biology Approaches to Engineer Probiotics and Members of the Human Microbiota for Biomedical Applications, Mathematical Modeling of RNA-Based Architectures for Closed Loop Control of Gene Expression, A detailed cell-free transcription-translation-based assay to decipher CRISPR protospacer-adjacent motifs, Genome Editing with CRISPR-Cas9 in Lactobacillus plantarum Revealed That Editing Outcomes Can Vary Across Strains and Between Methods, The Francisella novicida Cas12a is sensitive to the structure downstream of the terminal repeat in CRISPR arrays, What Is the Role of Circuit Design in the Advancement of Synthetic Biology? Department of Chemical and Biomolecular Engineering, North Carolina State University. 4 Helmholtz Institute of RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), 97080 Würzburg, Germany. (2011), Beisel CL, Storz G ... Movie presentation followed by a discussion with HIRI scientists Jörg Vogel and Chase Beisel. Our group is based in the Department of Chemical and Biomolecular Engineering at North Carolina State University. (2018), Liao C, Slotkowski RA, Achmedov T, Beisel CL (2011), Beisel CL, Chen YY, Culler SJ, Hoff KG, Smolke CD Appl Environ Microbiol. 5 Faculty of Medicine, University of Würzburg, 97078 Würzburg, Germany. 2 / Bau D15, 97080 Würzburg, Germany. Active projects center on developing genetic tools for non-model microbes and understanding and engineering CRISPR-Cas immune systems. These prokaryotic defense systems naturally cleave and degrade genetic material associated with … Coding Classes. RNA is a ubiquitous molecule of life that plays intimate roles in how cells function and make decisions. These systems use RNA to recognize matching genetic material from selfish genetic elements bent on infecting these microbes. 11/21/2017. From an engineering perspective, each discovery creates the opportunity to develop new technologies to improve how we gauge our health and treat diseases that afflict us. RNA Biol (2011) 8:1-5. (2020), Pickar-Oliver A, Black JB, Lewis MM, Mutchnick KJ, Klann TS, Gilcrest KA, Sitton MJ, Nelson CE, Barrera A, Bartelt LC, …, Barrangou R, Gersbach CA (2019), Jacobsen T, Liao C, Beisel CL Coinfection: More than the sum of its parts 18.11.2020 HIRI researchers and partners establish new technology to unravel genetic changes during infection with two different pathogens. (2014), In: Artificial Riboswitches (ed Ogawa A), Methods Mol Biol, 1111: 259-67, Afroz T, Biliouris K, Kaznessis Y, Beisel CL Dr. Lisa Beisel, MD, Psychiatrist, Austin, TX, 78746, (512) 270-3858, Welcome to my practice! (2016), Luo ML, Beisel CL This new genetic tool can make the therapy of cancer , AIDS or hereditary diseases possible. (2019), Rapid Communications In Mass Spectrometry, 33 (11): 1036-1048, Westbrook A, Tang X, Marshall R, Maxwell CS, Chappell J, Agrawal DK, Dunlop MJ, Noireaux V, Beisel CL, Lucks J, Franco E attachment from Maeola Beitzel. (2016), Journal of Bacteriology, 198 (3): 374-376, Luo ML, Leenay RT, Beisel CL Part 1, Deciphering, Communicating, and Engineering the CRISPR PAM, Toward a genetic tool development pipeline for host-associated bacteria, Short DNA containing χ sites enhances DNA stability and gene expression in E. coli cell-free transcription-translation systems, Advancing the design and delivery of CRISPR antimicrobials, The CRISPR RNA-guided surveillance complex in Escherichia coli accommodates extended RNA spacers, Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas Systems, Rethinking the Hierarchy of Sugar Utilization in Bacteria, Current and future prospects for CRISPR-based tools in bacteria, Efficient Delivery of CRISPR-Cas9 for Genome Editing via Self-Assembled DNA Nanoclews**, Trade-offs in engineering sugar utilization pathways for titratable control, Impact of Residual Inducer on Titratable Expression Systems, Repurposing endogenous type I CRISPR-Cas systems for programmable gene repression, A CRISPR design for next-generation antimicrobials, Guide RNA functional modules direct Cas9 activity and orthogonality, Construction of ligand-responsive microRNAs that operate through inhibition of Drosha processing, Bacterial sugar utilization gives rise to distinct single-cell behaviours, Programmable removal of bacterial strains by use of genome-targeting CRISPR-Cas systems, Understanding and exploiting feedback in synthetic biology, Multiple factors dictate target selection by Hfq-binding small RNAs, The base pairing RNA Spot 42 participates in a multi-output feedforward loop to help enact catabolite repression in Escherichia coli, Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing, Discriminating tastes: physiological contributions of the Hfq-binding small RNA Spot 42 to catabolite repression, Base pairing small RNAs and their roles in global regulatory networks, Synthetic control of a fitness tradeoff in yeast nitrogen metabolism, Design Principles for Riboswitch Function, Model-guided design of ligand-regulated RNAi for programmable control of gene expression, Conformational analysis of gossypol and its derivatives by molecular mechanics, Cochlear whole mount in situ hybridization: identification of longitudinal and radial gradients.
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